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Structure of 82099-98-7
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This pyrazole derivative features a bromine substituent at the 4-position and a tetrahydropyran-2-yl group at the 1-position, providing enhanced stability and solubility. The electron-deficient pyrazole core facilitates efficient coupling reactions, while the protecting group enables selective deprotection under mild conditions. This combination supports streamlined synthesis in medicinal chemistry applications.
4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The tetrahydropyran-2-yl protecting group offers excellent stability under basic and mild acidic conditions, facilitating orthogonal deprotection and simplifying purification. Its bromine substituent provides reliable reactivity in Suzuki, Stille, and Negishi couplings, making it well-suited for constructing complex heterocyclic scaffolds and diversifying molecular libraries with high reproducibility.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: