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Structure of 824431-97-2
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4-Iodo-2-methyl-1-(2,2,2-trifluoroethyl)-1H-imidazole features a sterically accessible imidazole core functionalized with a trifluoroethyl group and an iodine substituent at the 4-position. This combination delivers enhanced stability and tailored electronic properties, enabling efficient coupling in cross-coupling reactions. The molecule exhibits favorable solubility in common organic solvents and maintains integrity under standard bench conditions.
4-Iodo-2-methyl-1-(2,2,2-trifluoroethyl)-1H-imidazole serves as a versatile building block for constructing bioactive imidazole scaffolds in medicinal chemistry. The iodo group enables efficient palladium-catalyzed cross-coupling reactions, while the trifluoromethyl ether functionality enhances metabolic stability and modulates lipophilicity. This compound exhibits excellent bench stability, facilitates straightforward purification, and demonstrates broad functional group tolerance in standard coupling protocols.
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Lot numbers can be found on the outside label of a product: