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Structure of 828-81-9
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This thiadiazole derivative features a 2-chlorophenyl group linked to a [1,3,4]thiadiazol-2-ylamine scaffold, delivering enhanced electronic modulation and metabolic stability. The electron-deficient heterocycle enables efficient coupling in cross-coupling protocols, while the chloro substituent facilitates further functionalization via palladium-catalyzed transformations. Bench-stable and compatible with standard reaction conditions, this compound serves as a key building block for bioactive molecule synthesis.
5-(2-Chlorophenyl)-[1,3,4]thiadiazol-2-ylamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization protocols. Its ortho-chlorophenyl group enhances electrophilic reactivity and facilitates downstream derivatization via palladium-catalyzed cross-coupling. The thiadiazole scaffold provides metabolic stability and favorable pharmacokinetic properties, while the primary amine functionality allows for facile conjugation and salt formation. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses of targeted scaffolds.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: