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CS-W001157 4
Total: USD 88.00

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine

  • CAS No. 83792-48-7

  • Cat. No. CS-W009693
  • Purity≥97%
  • MDL No.MFCD00065674

*For research and further manufacturing use only, not for direct human use.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine|CS-W009693

Structure of 83792-48-7

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General Information

  • CAS No. 83792-48-7
  • Cat. No. CS-W009693
  • Purity ≥97%
  • MDL No. MFCD00065674
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₃NO₅
  • Molecular Weight 417.45
  • Synonym(s) None
  • SMILES O=C(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)N[C@H](C(O)=O)COCC4=CC=CC=C4

Description

Fmoc-Phe-serine-OH integrates a fluoren-9-ylmethoxycarbonyl (Fmoc) protecting group with a phenylmethyl (Phe) ester on the serine hydroxyl, enabling selective deprotection in solid-phase peptide synthesis. This configuration supports efficient coupling and orthogonal handling, delivering high yields during sequence assembly.

Application

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine serves as a protected amino acid building block for peptide synthesis, enabling orthogonal protection of both hydroxyl and amine functionalities. The Fmoc group ensures stable N-terminal protection under basic conditions, while the benzyl ether protects the serine side-chain hydroxyl with high fidelity. This derivative facilitates efficient coupling reactions, exhibits excellent solubility in organic solvents, and simplifies purification by standard chromatographic methods. Its bench-stable nature supports reliable handling in multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335-H332
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   4.1951
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   8

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