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CS-W001157 4
Total: USD 88.00

Fmoc-MeSer(Bzl)-OH

  • CAS No. 84000-14-6

  • Cat. No. CS-W009674
  • Purity≥97%
  • MDL No.MFCD00235880

*For research and further manufacturing use only, not for direct human use.

Fmoc-MeSer(Bzl)-OH|CS-W009674

Structure of 84000-14-6

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General Information

  • CAS No. 84000-14-6
  • Cat. No. CS-W009674
  • Purity ≥97%
  • MDL No. MFCD00235880
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₂₅NO₅
  • Molecular Weight 431.49
  • Synonym(s) None
  • SMILES CN([C@@H](COCC1=CC=CC=C1)C(O)=O)C(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2

Description

Fmoc-MeSer(Bzl)-OH is a protected serine derivative featuring a benzylated hydroxyl group and a methylation at the side chain, enabling selective incorporation in peptide synthesis. The Fmoc group ensures efficient orthogonal deprotection, while the benzyl protection offers enhanced stability during coupling steps. This variant facilitates the installation of methylated, hydroxylated residues in bioactive peptides under standard conditions.

Application

Fmoc-MeSer(Bzl)-OH serves as a versatile building block in peptide synthesis, enabling the incorporation of methylated serine with orthogonal protection. The Fmoc group facilitates efficient N-terminal deprotection under mild basic conditions, while the benzyl ether protects the hydroxyl functionality against side reactions. This combination offers excellent bench stability, compatibility with standard coupling protocols, and simplifies purification in complex peptide sequences.

Synthesis

  • Route1
    • null|null
      84000-04-4
    • ~97%
    • In-stock
      Fmoc-MeSer(Bzl)-OH|CS-W009674
      84000-14-6

    References

    • Buba, Annette E.; Koch, Stefan; Kunz, Horst; Loewe, Holger European Journal of Organic Chemistry, 2013 , # 21 p. 4509 - 4513
  • Route2

    References

    • European Journal of Organic Chemistry, , # 21 p. 4509 - 4513

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   4.5373
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   8

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