Methyl 4-amino-3-chlorobenzoate

Name: Methyl 4-amino-3-chlorobenzoate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 84228-44-4
Cat. No. CS-W016935
Purity≥98%
MDL No.MFCD01320686

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 4-amino-3-chlorobenzoate|CS-W016935

Structure of 84228-44-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 84228-44-4
Cat. No. CS-W016935
Purity ≥98%
MDL No. MFCD01320686
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClNO₂
Molecular Weight 185.61
Synonym(s) 4-Amino-3-chlorobenzoic Acid Methyl Ester
SMILES COC(=O)C1=CC(Cl)=C(N)C=C1

Description

Methyl 4-amino-3-chlorobenzoate features a para-amino group flanked by an ortho-chloro substituent on the aromatic ring, enabling selective coupling reactions in pharmaceutical synthesis. The ester functionality supports straightforward derivatization, while the electron-donating amino group enhances reactivity at the adjacent position. This compound serves as a key intermediate in the development of bioactive molecules requiring precise substitution patterns.

Application

Methyl 4-amino-3-chlorobenzoate serves as a versatile building block in medicinal chemistry, enabling direct access to substituted benzimidazoles and other heterocyclic scaffolds via cyclization reactions. The ortho-chloro group facilitates palladium-catalyzed coupling processes, while the methyl ester and primary amine functionalities allow for selective derivatization. Bench-stable and readily purified by recrystallization, it functions efficiently in multi-step syntheses requiring orthogonal functional group handling.

Synthesis

Route1
- 67-56-1
- In-stock
  
  2486-71-7
- ~99%
- In-stock
  
  84228-44-4
References
- Chen, Li; Feng, Lichun; Huang, Mengwei; Liu, Yongfu; Wu, Guolong; Wu, Jim Zhen; Zhou, Mingwei Patent: US2011/257151 A1, 2011 ; Location in patent: Page/Page column 75 ;
Route2
- In-stock
  
  619-45-4
- ~93%
- In-stock
  
  84228-44-4
References
- Zanka, Atsuhiko; Kubota, Ariyoshi Synlett, 1999 , # 12 p. 1984 - 1986
Route3
- In-stock
  
  21803-75-8
- ~%
- In-stock
  
  84228-44-4
References
- Journal of Medicinal Chemistry, , vol. 42, # 25 p. 5277 - 5283

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 52.32
LogP 1.7088
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

Methyl 4-amino-3-chlorobenzoate sigmaMethyl 4-amino-3-chlorobenzoate manufacturerMethyl 4-amino-3-chlorobenzoate priceMethyl 4-amino-3-chlorobenzoate structureMethyl 4-amino-3-chlorobenzoate SDSbuy Methyl 4-amino-3-chlorobenzoateMethyl 4-amino-3-chlorobenzoate supplierMethyl 4-amino-3-chlorobenzoate usesMethyl 4-amino-3-chlorobenzoate molecular weightprice of Methyl 4-amino-3-chlorobenzoateMethyl 4-amino-3-chlorobenzoate chemical name formula of Methyl 4-amino-3-chlorobenzoate

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Methyl 4-amino-3-chlorobenzoate

CAS No. 84228-44-4

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words