1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid

Name: 1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 84348-38-9
Cat. No. CS-0009247
Purity≥97%
MDL No.MFCD01861787

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1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid|CS-0009247

Structure of 84348-38-9

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Description

1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid is a stereochemically defined, bench-stable building block featuring a pyrrolidine core with a strategically positioned methylene group and a Boc-protected carboxylic acid. This configuration enables direct incorporation into complex heterocyclic scaffolds and facilitates efficient diversification in medicinal chemistry campaigns.

Application

1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid serves as a versatile chiral building block for the synthesis of pyrrolidine-containing scaffolds. Its protected amine and exocyclic methylene group enable efficient functionalization, facilitating C–C bond formation and heterocycle construction under standard coupling conditions. The Boc group provides bench stability and simplifies purification, while the (S)-configuration ensures stereochemical fidelity in downstream transformations relevant to medicinal chemistry and process development.

General Information

CAS No. 84348-38-9
Cat. No. CS-0009247
Purity ≥97%
MDL No. MFCD01861787
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₇NO₄
Molecular Weight 227.26
Synonym(s) N-Boc-4-methylene-L-proline
SMILES O=C([C@H](C1)N(C(OC(C)(C)C)=O)CC1=C)O

Computational Chemistry Data

TPSA 66.84
LogP 1.6366
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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1-Boc-(S)-4-Methylenepyrrolidine-2-carboxylic acid

CAS No. 84348-38-9

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