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CS-W001157 4
Total: USD 88.00

Tris(2-fluorophenyl)phosphine

  • CAS No. 84350-73-2

  • Cat. No. CS-0160275
  • Molecule weight316.26
  • Purity≥98%
  • MDL No.MFCD00015721

*For research and further manufacturing use only, not for direct human use.

Tris(2-fluorophenyl)phosphine|CS-0160275

Structure of 84350-73-2

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General Information

  • CAS No. 84350-73-2
  • Cat. No. CS-0160275
  • Purity ≥98%
  • MDL No. MFCD00015721
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₂F₃P
  • Molecular Weight 316.26
  • Synonym(s) Tris(2-fluorophenyl)phosphane
  • SMILES FC1=CC=CC=C1P(C2=CC=CC=C2F)C3=CC=CC=C3F

Description

Tris(2-fluorophenyl)phosphine is a sterically hindered, bench-stable phosphine ligand featuring electron-deficient aryl groups that enhance oxidative stability. This ligand integrates readily into palladium-catalyzed cross-coupling reactions, offering improved performance in challenging substrates where conventional phosphines fail.

Application

Tris(2-fluorophenyl)phosphine serves as a robust, bench-stable ligand in palladium-catalyzed cross-coupling reactions, enabling efficient C–C and C–heteroatom bond formation under mild conditions. Its electron-deficient character enhances catalyst turnover and improves reaction selectivity in challenging substrates. The fluorinated aryl groups confer enhanced stability and facilitate purification through improved chromatographic resolution, making it particularly valuable in medicinal chemistry and process-scale synthesis.

Synthesis

  • Route1

    References

    • Stegmann, H. B.; Kuehne, H.-M.; Wax, G.; Scheffler, K. Phosphorus and Sulfur and the Related Elements, 1982 , vol. 13, p. 331 - 336

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.8621
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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