1-(3-Bromophenyl)-2,2,2-trifluoroethan-1-amine

Name: 1-(3-Bromophenyl)-2,2,2-trifluoroethan-1-amine
Brand: ChemScene
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CAS No. 843608-45-7
Cat. No. CS-0326300
Purity≥97%
MDL No.None

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1-(3-Bromophenyl)-2,2,2-trifluoroethan-1-amine|CS-0326300

Structure of 843608-45-7

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General Information

CAS No. 843608-45-7
Cat. No. CS-0326300
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇BrF₃N
Molecular Weight 254.05
Synonym(s) 1-(3-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE
SMILES NC(C1=CC=CC(Br)=C1)C(F)(F)F

Description

This trifluoromethylated arylamine integrates a brominated phenyl moiety with a reactive amine handle, enabling direct coupling in cross-coupling and C–N bond formation. The electron-deficient aromatic ring enhances electrophilicity, while the bench-stable trifluoromethyl group improves metabolic resistance and lipophilic character for synthetic applications.

Application

1-(3-Bromophenyl)-2,2,2-trifluoroethan-1-amine serves as a versatile building block for the synthesis of fluorinated aromatic amines. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the bromo substituent enables subsequent cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings. The amine functionality provides a handle for derivatization, and the compound exhibits good bench stability and ease of purification, making it suitable for medicinal chemistry campaigns and process development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 3.0112
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-(3-Bromophenyl)-2,2,2-trifluoroethan-1-amine

CAS No. 843608-45-7

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