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Structure of 845617-99-4
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3-Chloro-5-(trifluoromethyl)pyridazine is a fluorinated heterocyclic building block featuring a chloro group at the 3-position and a trifluoromethyl moiety at the 5-position. This electron-deficient pyridazine core enables selective coupling reactions in medicinal chemistry, particularly in the development of kinase inhibitors and agrochemicals. The molecule exhibits enhanced metabolic stability and lipophilicity, facilitating membrane permeability.
3-Chloro-5-(trifluoromethyl)pyridazine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridazine scaffolds via palladium-catalyzed cross-coupling reactions. The chlorine atom at the 3-position facilitates nucleophilic substitution, while the trifluoromethyl group enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: