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CS-W001157 4
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tert-Butyl 2-hydroxypyrrolidine-1-carboxylate

  • CAS No. 84766-91-6

  • Cat. No. CS-D0581
  • Purity≥95%
  • MDL No.MFCD09031185
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-hydroxypyrrolidine-1-carboxylate|CS-D0581

Structure of 84766-91-6

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Description

tert-Butyl 2-hydroxypyrrolidine-1-carboxylate features a hydroxylated pyrrolidine core protected by a tert-butoxycarbonyl group, offering enhanced stability and solubility in polar organic solvents. This scaffold integrates readily into complex molecular architectures, serving as a key intermediate in asymmetric synthesis and medicinal chemistry. The pendant hydroxyl group enables further derivatization via oxidation or coupling reactions.

Application

tert-Butyl 2-hydroxypyrrolidine-1-carboxylate serves as a versatile pyrrolidine scaffold building block, enabling efficient access to functionalized heterocycles through standard transformations. The hydroxyl group provides a handle for selective derivatization, while the tert-butyl carbamate offers robust protection under acidic and basic conditions. Its bench stability and ease of purification make it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

General Information

  • CAS No. 84766-91-6
  • Cat. No. CS-D0581
  • Purity ≥95%
  • MDL No. MFCD09031185
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₇NO₃
  • Molecular Weight 187.24
  • Synonym(s) N-Boc-Pyrrolidin-2-Ol
  • SMILES OC1CCCN1C(OC(C)(C)C)=O

Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.3357
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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