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Structure of 847664-65-7
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2,5-Dichloropyridin-4-ol features a pyridinol core bearing two chlorine substituents at the 2 and 5 positions, enhancing its electrophilic character at the 4-position. This configuration enables efficient coupling in cross-coupling reactions, particularly under palladium catalysis. The molecule exhibits good bench stability and solubility in common organic solvents, facilitating use in synthetic workflows. Its electron-deficient heterocyclic framework supports selective functionalization, making it valuable for constructing complex pharmaceutical intermediates and agrochemical scaffolds.
2,5-Dichloropyridin-4-ol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient late-stage functionalization via nucleophilic substitution. Its dichloro pattern at the 2- and 5-positions provides orthogonal reactivity for selective derivatization, while the phenolic hydroxyl group enhances solubility and facilitates downstream conjugation. The compound exhibits good bench stability and is compatible with standard coupling protocols, making it well-suited for modular synthesis of heterocyclic scaffolds and targeted molecular libraries.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: