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Structure of 849934-93-6
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Methyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate is a bench-stable boronate ester featuring a sterically hindered tertiary carbon center. This structure enables efficient Suzuki-Miyaura coupling under mild conditions, delivering arylated products with high regioselectivity. The tetramethyl-substituted dioxaborolane moiety enhances stability and solubility in organic solvents.
Methyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The sterically protected tetramethylborolane moiety ensures excellent shelf stability and functional group tolerance, enabling efficient C–C bond formation under mild conditions. This reagent facilitates the rapid assembly of substituted biaryl scaffolds and is particularly valuable in medicinal chemistry for constructing complex heterocyclic and pharmaceutical intermediates with predictable regiochemistry and high yield.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: