6-Thioguanosine

Name: 6-Thioguanosine
Brand: ChemScene
Availability: InStock
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CAS No. 85-31-4
Cat. No. CS-0068553
Purity≥95%
MDL No.MFCD23102202

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 85-31-4

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Description

6-Thioguanosine integrates a thiopurine scaffold with enhanced metabolic stability and targeted incorporation into nucleic acids. This analog features a sulfur substitution at the C6 position, enabling selective engagement in DNA/RNA synthesis pathways. The modified base pairs efficiently with cytosine while resisting enzymatic degradation, making it valuable for probing nucleic acid dynamics and developing site-specific probes.

Application

6-Thioguanosine serves as a valuable nucleoside building block for the synthesis of thiopurine analogs and thio-modified oligonucleotides. Its thiol group at the C6 position enables site-specific conjugation and metal coordination, facilitating applications in probe development and targeted delivery systems. The molecule exhibits good bench stability and compatibility with standard deprotection protocols, enabling straightforward incorporation into complex synthetic sequences.

General Information

CAS No. 85-31-4
Cat. No. CS-0068553
Purity ≥95%
MDL No. MFCD23102202
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₃N₅O₄S
Molecular Weight 299.31
Synonym(s) 6-Mercaptoguanosine
SMILES NC1=NC(C2=C(N1)N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=S

Computational Chemistry Data

TPSA 142.44
LogP -1.31741
H_Acceptors 9
H_Donors 5
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Life Science Nucleosides & Nucleotides Nucleosides, Deoxyribonucleosides and Other Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

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6-Thioguanosine

CAS No. 85-31-4

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