2,3-Difluoro-4-iodopyridine

Name: 2,3-Difluoro-4-iodopyridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 851386-34-0
Cat. No. CS-W006225
Molecule weight240.98
Purity≥98%
MDL No.MFCD09909609

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 851386-34-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 851386-34-0
Cat. No. CS-W006225
Purity ≥98%
MDL No. MFCD09909609
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂F₂IN
Molecular Weight 240.98
Synonym(s) Pyridine, 2,3-difluoro-4-iodo-
SMILES IC1=C(F)C(F)=NC=C1

Description

2,3-Difluoro-4-iodopyridine is a fluorinated heteroaryl iodide featuring strategic electronic tuning via adjacent fluorine atoms. This bench-stable scaffold enables efficient cross-coupling reactions, particularly in palladium-catalyzed transformations. The electron-deficient pyridine ring enhances reactivity in C–X bond formation, while the iodide group provides high functional group tolerance and predictable coupling efficiency. Ideal for constructing complex molecular architectures in medicinal chemistry and materials science.

Application

2,3-Difluoro-4-iodopyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive iodide handle. The difluoro substitution pattern enhances metabolic stability and modulates electronic properties, while the pyridine core provides a robust scaffold for drug discovery. Its bench-stable nature and compatibility with standard coupling conditions facilitate efficient synthesis of complex heterocyclic architectures.

Synthesis

Route1
- 1513-66-2
- ~%
- In-stock
  
  851386-34-0
References
- Synthesis, , # 1 p. 63 - 66

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 12.89
LogP 1.9644
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

2,3-Difluoro-4-iodopyridine sigma2,3-Difluoro-4-iodopyridine manufacturer2,3-Difluoro-4-iodopyridine price2,3-Difluoro-4-iodopyridine structure2,3-Difluoro-4-iodopyridine SDSbuy 2,3-Difluoro-4-iodopyridine2,3-Difluoro-4-iodopyridine supplier2,3-Difluoro-4-iodopyridine uses2,3-Difluoro-4-iodopyridine molecular weightprice of 2,3-Difluoro-4-iodopyridine2,3-Difluoro-4-iodopyridine chemical name formula of 2,3-Difluoro-4-iodopyridine

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2,3-Difluoro-4-iodopyridine

CAS No. 851386-34-0

Recommended Products