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CS-W001157 4
Total: USD 88.00

5,6-Difluoropicolinic acid

  • CAS No. 851386-38-4

  • Cat. No. CS-0088897
  • Purity≥97%
  • MDL No.MFCD09031175
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5,6-Difluoropicolinic acid|CS-0088897

Structure of 851386-38-4

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Description

5,6-Difluoropicolinic acid is a fluorinated pyridine carboxylic acid featuring two strategically positioned fluorine atoms that enhance metabolic stability and influence electronic properties. This electron-deficient heterocycle integrates readily into bioactive scaffolds, serving as a key building block in medicinal chemistry for modulating solubility, membrane permeability, and target binding affinity.

Application

5,6-Difluoropicolinic acid serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds through standard coupling and cyclization protocols. Its ortho-difluoro substitution enhances metabolic stability and modulates electronic properties, facilitating targeted interactions in biological systems. The carboxylic acid functionality allows straightforward derivatization via amide, ester, or amidation reactions, supporting diverse synthetic workflows. Bench-stable and compatible with common reaction conditions, it functions reliably in peptide-like conjugations and API development.

General Information

  • CAS No. 851386-38-4
  • Cat. No. CS-0088897
  • Purity ≥97%
  • MDL No. MFCD09031175
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₂
  • Molecular Weight 159.09
  • Synonym(s) 5,6-difluoropyridine-2-carboxylic Acid
  • SMILES O=C(C1=NC(F)=C(F)C=C1)O

Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.058
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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