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CS-W001157 4
Total: USD 88.00

5-Ethynyl-2-fluoropyridine

  • CAS No. 853909-08-7

  • Cat. No. CS-0044083
  • Purity≥97%
  • MDL No.MFCD13175289

*For research and further manufacturing use only, not for direct human use.

5-Ethynyl-2-fluoropyridine|CS-0044083

Structure of 853909-08-7

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General Information

  • CAS No. 853909-08-7
  • Cat. No. CS-0044083
  • Purity ≥97%
  • MDL No. MFCD13175289
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄FN
  • Molecular Weight 121.11
  • Synonym(s) None
  • SMILES FC1=NC=C(C#C)C=C1

Description

5-Ethynyl-2-fluoropyridine features a reactive alkyne group conjugated to an electron-deficient fluoropyridine ring, enabling efficient copper-catalyzed azide-alkyne cycloaddition. This combination delivers high chemoselectivity and stability under standard conditions, making it ideal for bioconjugation and probe synthesis in chemical biology workflows.

Application

5-Ethynyl-2-fluoropyridine serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to substituted pyridine scaffolds. Its orthogonal reactivity profile—combining a terminal alkyne with an electrophilic fluorinated pyridine ring—facilitates modular synthesis of functionalized heterocycles. The compound exhibits excellent bench stability and compatibility with standard reaction conditions, supporting straightforward purification and integration into complex molecular architectures.

Synthesis

  • Route1
    • null|null
      904694-32-2
    • ~31%
    • In-stock
      5-Ethynyl-2-fluoropyridine|CS-0044083
      853909-08-7

    References

    • Ube Industries, Ltd. Patent: EP1847545 A1, 2007 ; Location in patent: Page/Page column 40 ;
  • Route2

    References

    • US2014/30191 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.202
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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