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Structure of 858197-58-7
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2-Methyl-2-morpholinopropan-1-ol is a sterically hindered tertiary alcohol featuring a morpholine ring and a hydroxyl group at the 1-position. This structure imparts excellent solubility in polar aprotic solvents and enhances stability under basic conditions. The molecule serves as a robust scaffold for conjugate additions and acts as an effective nucleophilic catalyst in C–C bond-forming reactions.
2-Methyl-2-morpholinopropan-1-ol serves as a stable, bench-ready building block for the synthesis of morpholine-containing pharmaceutical intermediates and bioactive heterocycles. Its tertiary alcohol functionality enables straightforward derivatization via Mitsunobu or esterification reactions, while the morpholinyl group provides favorable solubility and metabolic stability. The molecule exhibits excellent functional group tolerance and facilitates efficient purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3259
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H318
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: