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Structure of 860994-58-7
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N-[(1R,2R)-2-Aminocyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]thiourea features a chiral cyclohexylamine scaffold paired with a strongly electron-deficient aryl thiourea moiety. This combination enables precise coordination in asymmetric catalysis and metal complexation. The trifluoromethyl groups enhance lipophilicity and metabolic stability, while the primary amine offers a reactive handle for further functionalization.
N-[(1R,2R)-2-Aminocyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]thiourea serves as a versatile scaffold for medicinal chemistry campaigns, enabling efficient access to diverse heterocyclic architectures via cyclization and functionalization. The thiourea moiety exhibits strong hydrogen-bonding capacity and enhanced metabolic stability, while the (1R,2R)-aminocyclohexyl group provides defined stereochemistry and conformational rigidity. Bench-stable and compatible with standard purification protocols, it facilitates scalable synthesis in target-oriented and fragment-based drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H413
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Precautionary Statements : P264-P270-P273-P330-P501
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Lot numbers can be found on the outside label of a product: