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tert-Butyl ((6-bromopyridin-3-yl)methyl)carbamate

  • CAS No. 864266-29-5

  • Cat. No. CS-0059180
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl ((6-bromopyridin-3-yl)methyl)carbamate|CS-0059180

Structure of 864266-29-5

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Description

tert-Butyl ((6-bromopyridin-3-yl)methyl)carbamate features a brominated pyridine scaffold with a stable, moisture-tolerant carbamate protecting group. This bench-stable reagent integrates readily into cross-coupling workflows, enabling efficient access to functionalized heterocycles through Pd-catalyzed transformations. The para-brominated site facilitates selective derivatization in complex molecular architectures.

Application

tert-Butyl ((6-bromopyridin-3-yl)methyl)carbamate serves as a versatile building block in medicinal chemistry, enabling the efficient construction of pyridine-based scaffolds. The bromine substituent facilitates palladium-catalyzed cross-coupling reactions, while the tert-butyl carbamate group provides stable nitrogen protection under standard reaction conditions. This compound exhibits excellent bench stability and simplifies purification due to its low polarity and resistance to hydrolysis, making it ideal for multi-step synthesis workflows requiring orthogonal functional group handling.

General Information

  • CAS No. 864266-29-5
  • Cat. No. CS-0059180
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅BrN₂O₂
  • Molecular Weight 287.15
  • Synonym(s) tert-butyl N-[(6-bromopyridin-3-yl)methyl]carbamate
  • SMILES O=C(OC(C)(C)C)NCC1=CC=C(Br)N=C1

Computational Chemistry Data

  • TPSA   51.22
  • LogP   2.8688
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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