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CS-W001157 4
Total: USD 88.00

2-(4-Morpholinyl)-5-(trifluoromethyl)benzoic acid

  • CAS No. 865471-20-1

  • Cat. No. CS-0647552
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(4-Morpholinyl)-5-(trifluoromethyl)benzoic acid|CS-0647552

Structure of 865471-20-1

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Description

This morpholinyl-substituted benzoic acid features a trifluoromethyl group at the meta position, enhancing electron-withdrawing character and metabolic stability. The pendant morpholine ring imparts solubility and hydrogen-bonding capacity, enabling integration into bioactive scaffolds for medicinal chemistry applications.

Application

2-(4-Morpholinyl)-5-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the morpholinyl moiety offers hydrogen-bonding capacity and solubility modulation. The carboxylic acid functionality facilitates direct coupling reactions, amide formation, or derivatization under standard conditions, supporting efficient route optimization in drug discovery campaigns.

General Information

  • CAS No. 865471-20-1
  • Cat. No. CS-0647552
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₂F₃NO₃
  • Molecular Weight 275.22
  • Synonym(s) None
  • SMILES O=C(O)C1=CC(C(F)(F)F)=CC=C1N2CCOCC2

Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.2402
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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