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CS-W001157 4
Total: USD 88.00

3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride

  • CAS No. 86604-75-3

  • Cat. No. CS-0016107
  • Purity≥98%
  • MDL No.MFCD00277472

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride|CS-0016107

Structure of 86604-75-3

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General Information

  • CAS No. 86604-75-3
  • Cat. No. CS-0016107
  • Purity ≥98%
  • MDL No. MFCD00277472
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃Cl₂NO
  • Molecular Weight None
  • Synonym(s) Cc-993; Omeprazole chloride compound
  • SMILES ClCC1=NC=C(C)C(OC)=C1C.Cl

Description

TAMRA-PEG4-acid is a TAMRA red-fluorescent dye linker, with excitation/emission maximum 553/575 nm, containing an carboxylic acid group, which can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Application

3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride serves as a versatile pyridyl building block for medicinal chemistry and process development. The chloromethyl group enables efficient nucleophilic substitution reactions, while the methoxy and methyl substituents provide enhanced stability and favorable electronic modulation. This compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for multi-step synthesis of functionalized heterocycles and API intermediates.

Synthesis

  • Route1
    • (4-Methoxy-3,5-dimethylpyridin-2-yl)methanol Esomeprazole Impurity|CS-0214070
      86604-78-6
    • ~99%
    • In-stock
      3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride|CS-0016107
      86604-75-3

    References

    • Garst, Michael E.; Dolby, Lloyd Jay; Esfandiari, Shervin; MacKenzie, Vivian Rose; Avey JR., Alfred Arthur; Muchmore, David Charles; Cooper, Geoffrey Kenneth; Malone, Thomas C. Patent: US2005/38076 A1, 2005 ; Location in patent: Page/Page column 6 ;
  • Route2
    • 2-Pyridinemethanol, 4-methoxy-3,5-dimethyl-, hydrochloride 1:1|CS-0643127
      96300-88-8
    • ~%
    • In-stock
      3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride|CS-0016107
      86604-75-3

    References

    • WO2008/102145 A2, ; Page/Page column 19-20 ;
  • Route3
    • null|null
      67-63-0
    • 4-Methoxy-3,5-dimethylpicolinonitrile|CS-0377335
      104916-41-8
    • ~%
    • In-stock
      3,5-Dimethyl-2-chloromethyl-4-methoxypyridine hydrochloride|CS-0016107
      86604-75-3

    References

    • US5066810 A1, ;

Safety Information

Download SDS
GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.86764
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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