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Structure of 867256-77-7
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2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid delivers a boronate handle ortho to a fluorinated aromatic ring and adjacent to a carboxylic acid group. This configuration enables direct coupling in Suzuki-Miyaura reactions with minimal purification. The tetramethyl-substituted dioxaborolane enhances stability under standard conditions. The molecule integrates readily into complex scaffolds requiring selective functionalization.
2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The ortho-fluoro substituent enhances reactivity and enables sequential functionalization, while the tetramethylboronate group offers excellent stability, mild reaction conditions, and compatibility with diverse functional groups. This compound facilitates efficient construction of biaryl scaffolds and is well-suited for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: