2-Bromo-6-chloro-3-methylpyridine

Name: 2-Bromo-6-chloro-3-methylpyridine
Brand: ChemScene
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CAS No. 867377-03-5
Cat. No. CS-0112932
Purity≥98%
MDL No.MFCD11044269

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Bromo-6-chloro-3-methylpyridine|CS-0112932

Structure of 867377-03-5

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Description

2-Bromo-6-chloro-3-methylpyridine features a sterically accessible pyridine core with complementary halogen handles enabling direct functionalization. The ortho-halogen arrangement supports efficient cross-coupling, while the methyl group enhances solubility and modulates electronic properties. This scaffold integrates readily into bioactive heterocycles and advanced materials under standard conditions.

Application

2-Bromo-6-chloro-3-methylpyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates efficient Suzuki, Stille, or Negishi couplings, while the chloro and methyl functionalities offer complementary sites for further functionalization. Bench-stable and readily purified by distillation, it supports scalable synthesis of substituted pyridine scaffolds relevant to pharmaceutical and agrochemical development.

General Information

CAS No. 867377-03-5
Cat. No. CS-0112932
Purity ≥98%
MDL No. MFCD11044269
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrClN
Molecular Weight 206.47
Synonym(s) Pyridine,2-bromo-6-chloro-3-methyl
SMILES CC1=CC=C(Cl)N=C1Br

Computational Chemistry Data

TPSA 12.89
LogP 2.80592
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-6-chloro-3-methylpyridine

CAS No. 867377-03-5

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