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Structure of 86845-27-4
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5-Bromo-2-methylbenzotrifluoride is a fluorinated aromatic building block featuring a bromine atom and a methyl group at meta and ortho positions relative to the trifluoromethyl group. This combination imparts enhanced electron deficiency and steric profile, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. The molecule exhibits bench-stable handling characteristics and tolerates a range of reaction conditions, making it suitable for synthesizing complex fluorinated scaffolds in medicinal chemistry and materials science applications.
5-Bromo-2-methylbenzotrifluoride serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its stable trifluoromethyl and bromo functional groups. The methyl substituent enhances electron density at the aromatic ring, improving reactivity in Suzuki-Miyaura and Stille couplings. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex fluorinated scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: