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Structure of 86845-28-5
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1-Bromo-3-methyl-5-(trifluoromethyl)benzene features a trifluoromethyl group that imparts enhanced metabolic stability and lipophilicity, while the bromine serves as a reactive handle for cross-coupling transformations. The meta-substituted methyl and trifluoromethyl groups create a sterically defined, electron-deficient aromatic core ideal for palladium-catalyzed reactions. This compound enables efficient access to complex fluorinated scaffolds in medicinal chemistry and materials synthesis.
1-Bromo-3-methyl-5-(trifluoromethyl)benzene serves as a versatile aryl halide building block for palladium-catalyzed cross-coupling reactions, including Suzuki, Stille, and Negishi couplings. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl substituent provides steric and electronic modulation. Its bench-stable nature and compatibility with diverse reaction conditions enable efficient construction of complex aromatic scaffolds relevant to agrochemical and pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: