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5-Acetamidopicolinic acid

  • CAS No. 86873-62-3

  • Cat. No. CS-0094236
  • Purity≥97%
  • MDL No.MFCD15475043

*For research and further manufacturing use only, not for direct human use.

5-Acetamidopicolinic acid|CS-0094236

Structure of 86873-62-3

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General Information

  • CAS No. 86873-62-3
  • Cat. No. CS-0094236
  • Purity ≥97%
  • MDL No. MFCD15475043
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O₃
  • Molecular Weight 180.16
  • Synonym(s) 5-Acetamidopyridine-2-carboxylic acid
  • SMILES O=C(C1=NC=C(NC(C)=O)C=C1)O

Description

5-Acetamidopicolinic acid features a pyridine ring bearing both carboxylic acid and acetamido substituents at the 5-position, enabling dual functionalization. This configuration supports integration into peptide conjugates and bioactive scaffolds, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Application

5-Acetamidopicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyridine-based pharmacophores. Its dual functionality—carboxylic acid and acetamido groups—supports diverse coupling reactions and derivatization strategies. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in peptide conjugation, heterocyclic scaffold construction, and API intermediate development.

Synthesis

  • Route1

    References

    • Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H. Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
  • Route2

    References

    • Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H. Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
  • Route3

    References

    • Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H. Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   79.29
  • LogP   0.7382
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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