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Structure of 869782-94-5
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This trifluoromethoxy-substituted indazole carboxylic acid features a polar, electron-deficient heterocyclic core that enhances solubility and metabolic stability. The para-trifluoromethoxy group imparts strong lipophilicity and resistance to oxidative degradation, while the carboxylic acid enables direct conjugation or salt formation. Designed for use in medicinal chemistry, it serves as a key scaffold in kinase inhibitor development and bioactive molecule engineering.
5-(Trifluoromethoxy)-1H-indazole-3-carboxylic acid serves as a versatile building block for medicinal chemistry campaigns, enabling the synthesis of bioactive heterocycles through standard amide coupling and Suzuki-Miyaura cross-coupling reactions. Its trifluoromethoxy group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates direct derivatization. The compound exhibits excellent bench stability and compatibility with common purification methods, supporting scalable synthesis in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: