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CS-W001157 4
Total: USD 88.00

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine dihydrochloride

  • CAS No. 870483-68-4

  • Cat. No. CS-0127607
  • Purity≥97%
  • MDL No.MFCD23232159

*For research and further manufacturing use only, not for direct human use.

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine dihydrochloride|CS-0127607

Structure of 870483-68-4

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General Information

  • CAS No. 870483-68-4
  • Cat. No. CS-0127607
  • Purity ≥97%
  • MDL No. MFCD23232159
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁Cl₂F₃N₂
  • Molecular Weight 275.10
  • Synonym(s) None
  • SMILES FC(C1=CC2=C(N=C1)CCNC2)(F)F.[H]Cl.[H]Cl

Description

This trifluoromethyl-substituted naphthyridine dihydrochloride features a rigid, electron-deficient heterocyclic core with enhanced solubility and stability under standard conditions. The dihydrochloride salt form improves handling and crystallinity, enabling straightforward integration into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine dihydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. The trifluoromethyl group enhances metabolic stability and membrane permeability, while the dihydrochloride salt form ensures excellent solubility and bench stability. It functions effectively in standard amine coupling reactions and facilitates downstream functionalization for drug discovery applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   2.5897
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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