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Structure of 871224-19-0
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Methyl 3-bromo-2-chlorobenzoate is a bifunctional aryl halide featuring strategically positioned bromo and chloro substituents on a methyl benzoate scaffold. This configuration enables selective cross-coupling reactions in synthetic organic chemistry, particularly in palladium-catalyzed transformations where divergent reactivity between the two halogens can be exploited. The ester group enhances solubility in common organic solvents while maintaining stability under standard reaction conditions.
Methyl 3-bromo-2-chlorobenzoate serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen functionality. The bromo group facilitates efficient Suzuki, Stille, or Negishi couplings, while the chloro substituent offers enhanced stability under reaction conditions. Its methyl ester group provides compatibility with standard hydrolysis and derivatization protocols. The compound exhibits excellent bench stability and ease of purification, making it well-suited for multi-step synthesis and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: