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Structure of 871332-97-7
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3-Methoxy-5-(trifluoromethyl)phenylboronic acid features a boronate moiety flanked by electron-rich methoxy and strongly electron-withdrawing trifluoromethyl groups, enabling efficient cross-coupling under standard conditions. The ortho-methoxy substitution enhances solubility and stability in polar solvents, while the para-trifluoromethyl group imparts enhanced metabolic resistance. This combination delivers high reactivity in Suzuki-Miyaura couplings with minimal protodeboronation.
3-Methoxy-5-(trifluoromethyl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its stability under ambient conditions, combined with excellent functional group tolerance and straightforward purification, makes it well-suited for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: