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CS-W001157 4
Total: USD 88.00

3-Methoxy-5-(trifluoromethyl)phenylboronic acid

  • CAS No. 871332-97-7

  • Cat. No. CS-W009508
  • Purity≥97%
  • MDL No.MFCD08056362
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-5-(trifluoromethyl)phenylboronic acid|CS-W009508

Structure of 871332-97-7

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Description

3-Methoxy-5-(trifluoromethyl)phenylboronic acid features a boronate moiety flanked by electron-rich methoxy and strongly electron-withdrawing trifluoromethyl groups, enabling efficient cross-coupling under standard conditions. The ortho-methoxy substitution enhances solubility and stability in polar solvents, while the para-trifluoromethyl group imparts enhanced metabolic resistance. This combination delivers high reactivity in Suzuki-Miyaura couplings with minimal protodeboronation.

Application

3-Methoxy-5-(trifluoromethyl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its stability under ambient conditions, combined with excellent functional group tolerance and straightforward purification, makes it well-suited for medicinal chemistry and process development workflows.

General Information

  • CAS No. 871332-97-7
  • Cat. No. CS-W009508
  • Purity ≥97%
  • MDL No. MFCD08056362
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BF₃O₃
  • Molecular Weight 219.95
  • Synonym(s) 3-Methoxy-5-(trifluoromethyl)benzeneboronic Acid (contains varying amounts of Anhydride)
  • SMILES COC1=CC(=CC(=C1)C(F)(F)F)B(O)O

Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.3938
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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