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Structure of 874622-79-4
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4-(Methylcarbamoyl)benzene-1-sulfonyl chloride features a sulfonyl chloride group flanked by an electron-rich aromatic ring and a methylcarbamoyl substituent, enabling direct coupling with amines under mild conditions. This reactivity profile supports rapid incorporation into bioconjugates and functionalized scaffolds, particularly in the synthesis of targeted therapeutics and probe molecules.
4-(Methylcarbamoyl)benzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of a methylcarbamoyl-substituted benzene sulfonamide moiety. It facilitates amide bond formation under mild conditions, exhibits good bench stability, and enables straightforward purification due to its reactivity profile. Widely used in medicinal chemistry and API intermediate synthesis, it functions effectively in nucleophilic substitution reactions with amines and alcohols, offering high functional group tolerance and compatibility with standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314-H335
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: