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Structure of 875781-41-2
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5-Bromo-3-(2-(trimethylsilyl)ethynyl)pyrazin-2-amine features a sterically shielded trimethylsilyl-protected alkyne, enabling stable coupling in Sonogashira reactions. The electron-deficient pyrazine core pairs with the bromo and amine functionalities for efficient cross-coupling and modular derivatization in medicinal chemistry and materials science applications.
5-Bromo-3-(2-(trimethylsilyl)ethynyl)pyrazin-2-amine serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions via its bromo and silyl-protected alkyne functionalities. The trimethylsilyl group provides excellent bench stability and facilitates subsequent desilylation or Sonogashira coupling under mild conditions. Its orthogonality and functional group tolerance make it ideal for constructing complex heterocyclic scaffolds and bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: