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Structure of 87674-20-2
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2-Acetyl-3-fluoropyridine features a fluorinated pyridine core paired with an acetyl group at the 2-position, enabling direct integration into heterocyclic synthesis. The electron-deficient aromatic ring facilitates nucleophilic substitution, while the acetyl moiety serves as a handle for further functionalization. This compound offers enhanced reactivity and stability under standard conditions.
2-Acetyl-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via nucleophilic substitution or transition-metal-catalyzed coupling. The fluorine substituent enhances metabolic stability and facilitates regioselective transformations. Its acetyl group offers dual reactivity—undergoing enolization for aldol-type reactions or serving as a handle for further derivatization. Bench-stable and compatible with standard purification protocols, it functions effectively in multi-step syntheses of heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: