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Structure of 877996-21-9
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Tert-butyl 3-iodo-2-methyl-1H-indole-1-carboxylate features a sterically hindered tert-butyl ester that enhances stability and simplifies purification. The iodine substituent at the 3-position enables efficient cross-coupling reactions, while the methyl group at C2 fine-tunes electronic properties. This indole derivative serves as a robust scaffold for synthesizing complex heterocyclic architectures in medicinal chemistry and materials science.
Tert-butyl 3-iodo-2-methyl-1H-indole-1-carboxylate serves as a versatile building block for the synthesis of substituted indoles via cross-coupling reactions. The iodide functionality enables reliable Pd-catalyzed coupling with aryl, vinyl, and heteroaryl boranes or stannanes, while the tert-butyl carbamate group provides stability and convenient deprotection under mild acidic conditions. Its methyl substitution at the 2-position enhances regioselectivity in downstream transformations, making it ideal for constructing complex heterocyclic scaffolds relevant to medicinal chemistry and agrochemical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: