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Structure of 880870-66-6
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5-Bromo-2-fluoro-3-methoxypyridine features a trifunctional pyridine core with complementary halogen and methoxy groups, enabling selective cross-coupling and functionalization in late-stage diversification. This bench-stable heterocycle integrates efficiently into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.
5-Bromo-2-fluoro-3-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine supports directed ortho-metalation and enhances metabolic stability. Its methoxy substituent provides favorable solubility and electronic modulation, making it well-suited for the synthesis of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: