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Structure of 882033-66-1
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4-Chloro-5-fluoro-7-azaindole is a heterocyclic scaffold featuring complementary halogen substituents that enable selective cross-coupling reactions. This electron-deficient azaindole integrates readily into pharmaceutical intermediates, offering enhanced solubility and metabolic stability compared to parent indole systems.
4-Chloro-5-fluoro-7-azaindole serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive scaffolds. Its orthogonal reactivity profile—wherein the chloro group undergoes palladium-catalyzed cross-coupling while the fluoro substituent offers site-specific functionalization—facilitates rapid diversification. The 7-azaindole core provides enhanced solubility and improved metabolic stability compared to indole analogs, making it valuable for lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: