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CS-W001157 4
Total: USD 88.00

3-Butyn-1-amine hydrochloride

  • CAS No. 88211-50-1

  • Cat. No. CS-0059198
  • Molecule weight105.57
  • Purity≥95%
  • MDL No.MFCD06658391

*For research and further manufacturing use only, not for direct human use.

3-Butyn-1-amine hydrochloride|CS-0059198

Structure of 88211-50-1

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General Information

  • CAS No. 88211-50-1
  • Cat. No. CS-0059198
  • Purity ≥95%
  • MDL No. MFCD06658391
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClN
  • Molecular Weight 105.57
  • Synonym(s) None
  • SMILES Cl.C#CCCN

Description

3-Butyn-1-amine hydrochloride offers a reactive alkyne handle paired with a primary amine, enabling efficient conjugation in click chemistry and bioconjugation workflows. This bench-stable salt features enhanced solubility in aqueous and polar organic media, facilitating straightforward incorporation into peptide, polymer, and small-molecule syntheses under standard conditions.

Application

3-Butyn-1-amine hydrochloride serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized alkynes and nitrogen-containing heterocycles. Its terminal alkyne functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the primary amine group supports facile derivatization and protection strategies. The hydrochloride salt enhances bench stability and solubility in polar solvents, simplifying handling and purification in multi-step syntheses.

Synthesis

  • Route1

    References

    • ELI LILLY AND COMPANY Patent: WO2007/28131 A1, 2007 ; Location in patent: Page/Page column 50 ; WO 2007/028131 A1
  • Route2
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    • In-stock
      3-Butyn-1-amine hydrochloride|CS-0059198
      88211-50-1

    References

    • RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN; MAYER, Günter; LÜNSE, Christina Elsbeth; SUCKLING, Colin; SCOTT, Fraser Patent: WO2013/117559 A1, 2013 ; Location in patent: Page/Page column 28; 29 ;
  • Route3

    References

    • Doetz, K. H.; Schaefer, T. O.; Harms, K. Synthesis, 1992 , # 1-2 p. 146 - 150

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.3902
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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