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Structure of 882679-14-3
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4-Chloro-5-methylpicolinic acid features a sterically accessible pyridine core with complementary electron-withdrawing and donating substituents. This combination enhances its utility in transition metal-catalyzed coupling reactions and as a scaffold in medicinal chemistry due to favorable solubility and stability under standard conditions.
4-Chloro-5-methylpicolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through standard coupling and cyclization reactions. Its ortho-chloro and methyl substituents provide defined electronic and steric profiles, enhancing reactivity in palladium-catalyzed cross-couplings and facilitating downstream functionalization. The carboxylic acid group offers direct handle for amide bond formation or derivatization, while the compound exhibits good bench stability and ease of purification—ideal for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: