Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

6-Chloro-2-fluoropyridin-3-ol

  • CAS No. 883107-68-4

  • Cat. No. CS-0156782
  • Molecule weight147.53
  • Purity≥98%
  • MDL No.MFCD07437887

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-fluoropyridin-3-ol|CS-0156782

Structure of 883107-68-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 883107-68-4
  • Cat. No. CS-0156782
  • Purity ≥98%
  • MDL No. MFCD07437887
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFNO
  • Molecular Weight 147.53
  • Synonym(s) 6-chloro-2-fluoro-3-hydroxypyridine
  • SMILES C1=CC(=NC(=C1O)F)Cl

Description

6-Chloro-2-fluoropyridin-3-ol features a trifunctional pyridine core bearing chlorine, fluorine, and hydroxyl groups at strategic positions. This electron-deficient heterocycle serves as a key scaffold in medicinal chemistry, enabling direct coupling reactions under mild conditions. The hydroxyl group enhances solubility and facilitates derivatization, while the adjacent halogen atoms support selective cross-coupling transformations.

Application

6-Chloro-2-fluoropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated heterocyclic scaffolds. Its orthogonal reactivity profile—where the chloro group undergoes palladium-catalyzed coupling and the hydroxyl group participates in derivatization—facilitates rapid diversification. Bench-stable and amenable to standard purification methods, it functions reliably in multi-step syntheses requiring functional group tolerance and predictable regiochemistry.

Synthesis

  • Route1

    References

    • AMGEN INC.; CHEN, Jian, J.; ZHONG, Wenge; YANG, Bryant; QIAN, Wenyuan; LOPEZ, Patricia; WHITE, Ryan; WEISS, Matthew; JUDD, Ted; POWERS, Timothy; CHENG, Yuan; DINEEN, Thomas; EPSTEIN, Oleg; LOW, Jonathan; MARX, Isaac; MINATTI, Ana Elena; PARAS, Nick, A.; POTASHMAN, Michele Patent: WO2011/115928 A1, 2011 ; Location in patent: Page/Page column 59 ; WO 2011/115928 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5797
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 6-Chloro-2-fluoropyridin-3-ol sigma6-Chloro-2-fluoropyridin-3-ol manufacturer6-Chloro-2-fluoropyridin-3-ol price6-Chloro-2-fluoropyridin-3-ol structure6-Chloro-2-fluoropyridin-3-ol SDSbuy 6-Chloro-2-fluoropyridin-3-ol6-Chloro-2-fluoropyridin-3-ol supplier6-Chloro-2-fluoropyridin-3-ol uses6-Chloro-2-fluoropyridin-3-ol molecular weightprice of 6-Chloro-2-fluoropyridin-3-ol6-Chloro-2-fluoropyridin-3-ol chemical name formula of 6-Chloro-2-fluoropyridin-3-ol
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label