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CS-W001157 4
Total: USD 88.00

(6-((tert-Butoxycarbonyl)amino)pyridin-3-yl)boronic acid

  • CAS No. 883231-20-7

  • Cat. No. CS-W006305
  • Purity≥97%
  • MDL No.MFCD11975411
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(6-((tert-Butoxycarbonyl)amino)pyridin-3-yl)boronic acid|CS-W006305

Structure of 883231-20-7

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Description

This boronate moiety integrates a tert-butoxycarbonyl-protected amine on a pyridine scaffold, enabling selective functionalization in late-stage diversification. The protected amine allows orthogonal reactivity, while the boronic acid group facilitates palladium-catalyzed cross-coupling under standard conditions. Bench-stable and moisture-tolerant, this building block supports efficient synthesis of bioactive heterocycles.

Application

(6-((tert-Butoxycarbonyl)amino)pyridin-3-yl)boronic acid serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. The protected amine moiety ensures stability during reaction conditions and facilitates selective deprotection post-coupling. Its pyridyl boronic acid framework supports efficient Suzuki-Miyaura coupling for constructing biaryl scaffolds, making it ideal for the synthesis of complex heterocyclic compounds and API intermediates.

General Information

  • CAS No. 883231-20-7
  • Cat. No. CS-W006305
  • Purity ≥97%
  • MDL No. MFCD11975411
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅BN₂O₄
  • Molecular Weight 238.05
  • Synonym(s) [6-[(tert-Butoxycarbonyl)amino]pyridin-3-yl]boronic acid
  • SMILES CC(C)(OC(NC1=CC=C(B(O)O)C=N1)=O)C

Computational Chemistry Data

  • TPSA   91.68
  • LogP   0.1084
  • H_Acceptors   5
  • H_Donors   3
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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