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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-iodonicotinic acid

  • CAS No. 884494-51-3

  • Cat. No. CS-0041297
  • Purity≥97%
  • MDL No.MFCD03095310
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-iodonicotinic acid|CS-0041297

Structure of 884494-51-3

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Description

2-Fluoro-4-iodonicotinic acid is a halogenated pyridine derivative featuring complementary fluorine and iodine substituents at ortho and para positions, respectively. This combination enables selective cross-coupling transformations in medicinal chemistry applications. The carboxylic acid group facilitates direct derivatization and incorporation into bioactive scaffolds. Bench-stable and moisture-tolerant, it streamlines synthetic access to functionalized heterocycles under standard conditions.

Application

2-Fluoro-4-iodonicotinic acid serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted nicotinates. The ortho-fluoro and meta-iodo groups offer complementary reactivity for sequential functionalization, with the carboxylic acid facilitating direct derivatization or salt formation. Bench-stable and compatible with standard purification protocols, it supports scalable synthesis of heterocyclic scaffolds relevant to medicinal chemistry and agrochemical research.

General Information

  • CAS No. 884494-51-3
  • Cat. No. CS-0041297
  • Purity ≥97%
  • MDL No. MFCD03095310
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃FINO₂
  • Molecular Weight 267.00
  • Synonym(s) 2-Fluoro-4-iodopyridine-3-carboxylic acid, 3-Carboxy-2-fluoro-4-iodopyridine
  • SMILES FC1=C(C(=O)O)C(=CC=N1)I

Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5235
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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