3-Bromo-5-fluoropyridin-2(1H)-one

Name: 3-Bromo-5-fluoropyridin-2(1H)-one
Brand: ChemScene
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CAS No. 884494-94-4
Cat. No. CS-0102949
Purity≥97%
MDL No.MFCD08277253

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Bromo-5-fluoropyridin-2(1H)-one|CS-0102949

Structure of 884494-94-4

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Description

3-Bromo-5-fluoropyridin-2(1H)-one features a fused heterocyclic core bearing strategically positioned halogen substituents, enabling direct functionalization in cross-coupling and nucleophilic substitution reactions. The electron-deficient pyridinone scaffold enhances reactivity toward amines and thiols, while the bromine and fluorine atoms provide orthogonal handles for sequential derivatization. This bench-stable compound integrates readily into complex molecular architectures used in medicinal chemistry and materials science.

Application

3-Bromo-5-fluoropyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal reactivity profile. The bromo group facilitates C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the fluorine and lactam functionalities provide enhanced metabolic stability and hydrogen-bonding capacity. Its bench-stable crystalline nature simplifies handling and purification, making it ideal for modular synthesis of bioactive heterocycles and API intermediates.

General Information

CAS No. 884494-94-4
Cat. No. CS-0102949
Purity ≥97%
MDL No. MFCD08277253
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃BrFNO
Molecular Weight 191.99
Synonym(s) 3-Bromo-5-fluoropyridin-2-OL
SMILES O=C1C(Br)=CC(F)=CN1

Computational Chemistry Data

TPSA 32.86
LogP 1.2765
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Bromo-5-fluoropyridin-2(1H)-one

CAS No. 884494-94-4

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