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CS-W001157 4
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4-Bromo-5-fluoro-2-methoxypyridine

  • CAS No. 884495-00-5

  • Cat. No. CS-0159569
  • Purity≥95%
  • MDL No.MFCD05662409

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-fluoro-2-methoxypyridine|CS-0159569

Structure of 884495-00-5

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General Information

  • CAS No. 884495-00-5
  • Cat. No. CS-0159569
  • Purity ≥95%
  • MDL No. MFCD05662409
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFNO
  • Molecular Weight 206.01
  • Synonym(s) pyridine, 4-bromo-5-fluoro-2-methoxy-
  • SMILES COC1=NC=C(F)C(Br)=C1

Description

4-Bromo-5-fluoro-2-methoxypyridine is a halogenated pyridine derivative featuring complementary electrophilic and nucleophilic sites. This bench-stable, moisture-tolerant heterocycle integrates readily into cross-coupling workflows, enabling efficient access to complex pharmaceutical scaffolds through Pd-catalyzed transformations.

Application

4-Bromo-5-fluoro-2-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine supports electrophilic substitution or directed ortho-metalation. Bench-stable and readily purified by column chromatography, it functions effectively in the synthesis of functionalized heterocycles and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.9918
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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