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5-Fluoro-4-iodo-2-methoxypyridine

  • CAS No. 884495-13-0

  • Cat. No. CS-0063932
  • Molecule weight253.01
  • Purity≥97%
  • MDL No.MFCD06659503

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-4-iodo-2-methoxypyridine|CS-0063932

Structure of 884495-13-0

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General Information

  • CAS No. 884495-13-0
  • Cat. No. CS-0063932
  • Purity ≥97%
  • MDL No. MFCD06659503
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FINO
  • Molecular Weight 253.01
  • Synonym(s) pyridine, 5-fluoro-4-iodo-2-methoxy-
  • SMILES COC1=NC=C(F)C(I)=C1

Description

5-Fluoro-4-iodo-2-methoxypyridine features a strategically positioned fluorine atom and iodine handle on a pyridine core, enabling selective cross-coupling transformations. The methoxy group enhances solubility and modulates electronic properties, while the electron-deficient ring facilitates palladium-catalyzed reactions under standard conditions. This bench-stable building block is well-suited for medicinal chemistry and materials synthesis.

Application

5-Fluoro-4-iodo-2-methoxypyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of substituted pyridine scaffolds. The iodine group facilitates reliable Suzuki, Stille, and Negishi couplings, while the fluorine and methoxy groups provide orthogonal reactivity and enhanced stability under standard reaction conditions. This compound is particularly valuable for medicinal chemistry applications requiring regioselective functionalization of heterocyclic cores.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.8339
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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