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Structure of 884495-23-2
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6-Fluoro-3-iodo-2-methylpyridine features a strategically positioned fluorine atom and iodine substituent on a pyridine core, enabling selective cross-coupling transformations. The electron-deficient aromatic ring, combined with the sterically accessible methyl group, supports efficient functionalization in late-stage diversification workflows. This bench-stable reagent integrates readily into synthetic sequences requiring halogen-directed C–H activation or palladium-catalyzed coupling.
6-Fluoro-3-iodo-2-methylpyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient access to substituted pyridine scaffolds. The iodo group facilitates palladium-catalyzed coupling reactions with broad functional group tolerance, while the fluorine and methyl groups provide orthogonal reactivity and electronic modulation. This compound exhibits excellent bench stability and is readily purified by distillation or flash chromatography, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: