4-Chloro-6-methoxy-2-methylpyrimidin-5-amine

Name: 4-Chloro-6-methoxy-2-methylpyrimidin-5-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 88474-31-1
Cat. No. CS-0045809
Purity≥97%
MDL No.MFCD01837887

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-6-methoxy-2-methylpyrimidin-5-amine|CS-0045809

Structure of 88474-31-1

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Description

4-Chloro-6-methoxy-2-methylpyrimidin-5-amine is a bench-stable heterocyclic building block featuring a chlorine substituent at C4, a methoxy group at C6, and a methyl group at C2. The electron-deficient pyrimidine core facilitates nucleophilic substitution reactions, while the primary amine at C5 enables facile conjugation. This compound integrates efficiently into pharmaceutical scaffolds and agrochemical intermediates under standard conditions.

Application

4-Chloro-6-methoxy-2-methylpyrimidin-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its orthogonal reactivity profile—combining a nucleophilic amine with an electrophilic chlorine—facilitates modular derivatization under mild conditions. The methoxy and methyl groups enhance solubility and modulate electronic properties, supporting scalable synthesis and purification by standard chromatographic methods.

General Information

CAS No. 88474-31-1
Cat. No. CS-0045809
Purity ≥97%
MDL No. MFCD01837887
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₈ClN₃O
Molecular Weight 173.60
Synonym(s) 5-Amino-4-chloro-6-methoxy-2-methylpyrimidine
SMILES NC1=C(OC)N=C(C)N=C1Cl

Computational Chemistry Data

TPSA 61.03
LogP 1.02922
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

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4-Chloro-6-methoxy-2-methylpyrimidin-5-amine

CAS No. 88474-31-1

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