2-(2-Bromo-4-hydroxyphenyl)acetic acid

Name: 2-(2-Bromo-4-hydroxyphenyl)acetic acid
Brand: ChemScene
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CAS No. 88491-44-5
Cat. No. CS-0226552
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-(2-Bromo-4-hydroxyphenyl)acetic acid|CS-0226552

Structure of 88491-44-5

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General Information

CAS No. 88491-44-5
Cat. No. CS-0226552
Purity ≥96%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇BrO₃
Molecular Weight 231.04
Synonym(s) 2-BROMO-4-HYDROXYPHENYLACETIC ACID
SMILES O=C(O)CC1=CC=C(O)C=C1Br

Description

This brominated phenolic acetic acid derivative features a hydroxyl group ortho to the bromine, enhancing its reactivity in coupling reactions. The carboxylic acid functionality enables direct conjugation or derivatization, while the electron-withdrawing bromine stabilizes adjacent intermediates. Ideal for synthesizing bioactive compounds and functional materials under standard conditions.

Application

2-(2-Bromo-4-hydroxyphenyl)acetic acid serves as a versatile building block for brominated aromatic scaffolds, enabling direct functionalization in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions. The carboxylic acid group facilitates derivatization via amide or ester formation, while the phenolic hydroxyl permits selective protection or etherification. Bench-stable and compatible with standard purification methods, it functions effectively in medicinal chemistry campaigns requiring halogenated aryl motifs.

Synthesis

Route1
- In-stock
  
  66916-99-2
- ~%
- In-stock
  
  88491-44-5
References
- TAKEDA PHARMACEUTICAL COMPANY LIMITED; YASUMA, Tsuneo; KAMATA, Makoto; YAMASHITA, Tohru; HIROSE, Hideki; MURAKAMI, Masataka; KINA, Asato; YONEMORI, Kazuko; MIZOJIRI, Ryo; FUJIMORI, Ikuo; FUJIMOTO, Takuya; IKEDA, Zenichi Patent: WO2012/74126 A1, 2012 ; Location in patent: Page/Page column 246 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

TPSA 57.53
LogP 1.7818
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-(2-Bromo-4-hydroxyphenyl)acetic acid

CAS No. 88491-44-5

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