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CS-W001157 4
Total: USD 88.00

6-Iodopyridin-2-amine

  • CAS No. 88511-25-5

  • Cat. No. CS-0029508
  • Purity≥96%
  • MDL No.MFCD07779511

*For research and further manufacturing use only, not for direct human use.

6-Iodopyridin-2-amine|CS-0029508

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General Information

  • CAS No. 88511-25-5
  • Cat. No. CS-0029508
  • Purity ≥96%
  • MDL No. MFCD07779511
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅IN₂
  • Molecular Weight 220.01
  • Synonym(s) Pyridine, 2-amino-6-iodo-; 6-Iodo-Pyridin-2-Ylamine
  • SMILES NC1=NC(I)=CC=C1

Description

6-Iodopyridin-2-amine features a reactive iodine atom at the 6-position and a primary amine group at the 2-position, enabling seamless incorporation into cross-coupling reactions. This bifunctional scaffold facilitates rapid access to diverse nitrogen-containing heterocycles in medicinal chemistry and materials science applications.

Application

6-Iodopyridin-2-amine serves as a versatile building block in cross-coupling chemistry, enabling efficient access to substituted pyridines via palladium-catalyzed reactions. The iodine and amine functionalities provide orthogonal reactivity for sequential functionalization, while the molecule exhibits excellent bench stability and compatibility with standard synthetic protocols. Its defined regiochemistry supports predictable transformations in medicinal chemistry and agrochemical research.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/60970 A1, 2005 ; Location in patent: Page/Page column 117 ; WO 2005/060970 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.2684
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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